<
 
 
 
 
×
>
hide You are viewing an archived web page, collected at the request of using Archive-It. This page was captured on 11:30:06 Mar 11, 2016, and is part of the University of Melbourne collection. The information on this web page may be out of date. See All versions of this archived page. Loading media information

News

Genetics Triumph

[ Research Review 0808 : Science ]

By Rebecca Scott

A world first – Tasmanian Tiger genes succeed in a mouse.

In a world first, researchers from the University of Melbourne, Australia, and the University of Texas, USA, have extracted genes from the extinct Tasmanian Tiger (thylacine), inserted it into a mouse and observed a biological function.

The results released in the international scientific journal PLoS ONE, showed that the thylacine Col2a1 gene has a similar function in developing cartilage and bone development as the Col2a1 gene does in the mouse.

“This is the first time that DNA from an extinct species has been used to induce a functional response in another living organism,” said Dr Andrew Pask, RD Wright Fellow at the University of Melbourne’s Department of Zoology who led the research.

“As more and more species of animals become extinct, we are continuing to lose critical knowledge of gene function and their potential. Up until now we have only been able to examine gene sequences from extinct animals. This research was developed to go one step further to examine extinct gene function in a whole organism,” he said.

“This research has enormous potential for many applications including the development of new biomedicines and gaining a better understanding of the biology of extinct animals,” said Professor Richard Behringer, Deputy Head of the Department of Molecular Genetics, M.D. Anderson Cancer Center, at the University of Texas, who is the corresponding author on the paper.

The last known Tasmanian Tiger died in captivity in the Hobart Zoo in 1936. This enigmatic marsupial carnivore was hunted to extinction in the wild in the early 1900s.

Researchers say fortunately some thylacine pouch young and adult tissues were preserved in alcohol in several museum collections around the world.

The research team used thylacine specimens from Museum Victoria to examine how the thylacine genome functioned.

The research team isolated DNA from 100-year-old ethanol fixed specimens. After authenticating this DNA as truly thylacine, it was inserted into mouse embryos and its function examined.

The thylacine DNA was resurrected, showing a function in the developing mouse cartilage, which will later form the bone.

“At a time when extinction rates are increasing at an alarming rate, especially of mammals, this research discovery is critical,” says Professor Marilyn Renfree, Federation Fellow and Laureate Professor in the University of Melbourne’s Department of Zoology, the senior author on the paper.

“For those species that have already become extinct, our method shows that access to their genetic biodiversity may not be completely lost.” 

More information about this article:

Rebecca Scott
Media Promotions Officer
rebeccas@unimelb.edu.au
Tel: +61 3 8344 0181
Mob: 0417 164 791

Dr Andrew Pask, RD Wright Fellow – Department of Zoology, University of Melbourne, email: ajpask@unimelb.edu.au

Professor Marilyn Renfree, Federation Fellow and Laureate Professor, Department of Zoology, email: m.renfree@unimelb.edu.au

See also Online Experts Guide

[Download pdf of this article]

[Back to Contents]

Thanks to the Tasmanian Museum and Art Gallery for the kind permission to reproduce photograph by Benjamin A. Sheppard of the male Tasmanian Tiger. [ Click to enlarge ]

---
top of page